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What is ALS?
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History
1850
English scientist Augustus Waller describes the appearance of shriveled nerve fibers
1869
French doctor Jean-Martin Charcot first describes ALS in scientific literature.
1881
"On Amyotrophic Lateral Sclerosis" is translated into English and published in a three-volume edition of Lectures on the Diseases of the Nervous System
1939
ALS becomes a cause célèbre in the United States when baseball legend Lou Gehrig's career—and, two years later, his life—is ended by the disease. He gives his farewell speech on July 4.
1950s
ALS epidemic occurs among the Chamorro people on Guam
1991
Researchers link chromosome 21 to FALS (Familial ALS)
1993
SOD1 gene on chromosome 21 found to play a role in some cases of FALS
1996
Rilutek becomes the first FDA-approved drug for ALS
1998
The El Escorial criteria is developed as the standard for classifying ALS patient in clinical research
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